Anti-Histone H2A.X抗体- ChIP Grade (ab11175)

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ab11175 被引用在 78 文献中.

  • Xiong H  et al. Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization. J Cancer 8:345-353 (2017). WB ; Human . PubMed: 28261334
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  • Ha K  et al. The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites. Nat Commun 8:15751 (2017). PubMed: 28604711
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  • Tang C  et al. Aspartate ß-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma. Oncogenesis 6:e362 (2017). PubMed: 28714949
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  • Xu C  et al. MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA. Oncotarget 7:77764-77776 (2016). ChIP ; Human . PubMed: 27780918
  • Ohno S  et al. Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2. Sci Rep 6:39091 (2016). PubMed: 27982046
  • Tanikawa M  et al. The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing. Oncogenesis 5:e280 (2016). WB ; Human . PubMed: 27991914
  • Jacobs K  et al. Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability. Stem Cell Reports 6:330-41 (2016). ICC/IF ; Human . PubMed: 26923824
  • Baleriola J  et al. Increased neuronal death and disturbed axonal growth in the Polµ-deficient mouse embryonic retina. Sci Rep 6:25928 (2016). WB ; Mouse . PubMed: 27172884
  • Coucoravas C  et al. Phosphorylation of the Cajal body protein WRAP53ß by ATM promotes its involvement in the DNA damage response. RNA Biol N/A:1-10 (2016). Human . PubMed: 27715493
  • Li L  et al. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat Commun 7:12235 (2016). WB ; Human . PubMed: 27436229
  • Pan H  et al. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res 26:190-205 (2016). WB ; Human . PubMed: 26768768
  • Nagy Z  et al. Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet 12:e1005791 (2016). Human . PubMed: 26845027
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  • Piya S  et al. Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Blood 128:1260-9 (2016). PubMed: 27268264
  • Ošina K  et al. Effects of an Antimutagenic 1,4-Dihydropyridine AV-153 on Expression of Nitric Oxide Synthases and DNA Repair-related Enzymes and Genes in Kidneys of Rats with a Streptozotocin Model of Diabetes Mellitus. Basic Clin Pharmacol Toxicol 119:458-463 (2016). PubMed: 27163882
  • Pederiva C  et al. Splicing controls the ubiquitin response during DNA double-strand break repair. Cell Death Differ 23:1648-57 (2016). PubMed: 27315300
  • Gruosso T  et al. Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients. EMBO Mol Med 8:527-49 (2016). WB, IHC . PubMed: 27006338
  • Zuazua-Villar P  et al. Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells. Nucleic Acids Res 43:9776-87 (2015). WB ; Human . PubMed: 26271993
  • Xiao H  et al. ?-H2AX promotes hepatocellular carcinoma angiogenesis via EGFR/HIF-1a/VEGF pathways under hypoxic condition. Oncotarget 6:2180-92 (2015). Human . PubMed: 25537504
  • Li X  et al. BRHIS1 suppresses rice innate immunity through binding to monoubiquitinated H2A and H2B variants. EMBO Rep 16:1192-202 (2015). Rice . PubMed: 26202491
  • Mihailovich M  et al. miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth. Nat Commun 6:8725 (2015). WB ; Mouse . PubMed: 26555894
  • Masuda Y  et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun 6:7299 (2015). Human . PubMed: 26095369
  • Gao R  et al. Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. PLoS Genet 11:e1004834 (2015). WB ; Human . PubMed: 25590633
  • Tarrade S  et al. Histone H2AX Is Involved in FoxO3a-Mediated Transcriptional Responses to Ionizing Radiation to Maintain Genome Stability. Int J Mol Sci 16:29996-30014 (2015). WB ; Mouse . PubMed: 26694365
  • Slaats GG  et al. DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome. J Clin Invest 125:3657-66 (2015). PubMed: 26301811
  • Gray K  et al. Effects of DNA damage in smooth muscle cells in atherosclerosis. Circ Res 116:816-26 (2015). WB . PubMed: 25524056
  • Kocylowski MK  et al. Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168. Cell Cycle 14:1748-58 (2015). WB ; Human . PubMed: 25695757
  • Wang L  et al. Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX. Chem Biol 22:849-61 (2015). Human . PubMed: 26119999
  • Jimeno-González S  et al. Defective histone supply causes changes in RNA polymerase II elongation rate and cotranscriptional pre-mRNA splicing. Proc Natl Acad Sci U S A 112:14840-5 (2015). Human . PubMed: 26578803
  • Rothbart SB  et al. An Interactive Database for the Assessment of Histone Antibody Specificity. Mol Cell 59:502-11 (2015). PubMed: 26212453
  • O'Sullivan RJ  et al. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol 21:167-74 (2014). WB ; Human . PubMed: 24413054
  • Su WP  et al. Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma. Oncotarget 5:6323-37 (2014). WB . PubMed: 25051366
  • Huang SC  et al. Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis. Sci Signal 7:ra20 (2014). PubMed: 24570488
  • Leung JW  et al. Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet 10:e1004178 (2014). WB ; Human . PubMed: 24603765
  • Shahar OD  et al. A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair. Nucleic Acids Res 42:5689-701 (2014). WB ; Human . PubMed: 24682826
  • Goshima T  et al. Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-?B signaling pathway. J Biol Chem 289:11656-66 (2014). WB ; Human . PubMed: 24584930
  • Oleson BJ  et al. Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent ?H2AX protein formation in pancreatic ß cells. J Biol Chem 289:11454-64 (2014). WB ; Rat . PubMed: 24610783
  • Inoue A & Zhang Y Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes. Nat Struct Mol Biol 21:609-16 (2014). IHC - Wholemount, ICC/IF ; Mouse . PubMed: 24908396
  • Knobel PA  et al. USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism. Mol Cell Biol 34:2062-74 (2014). WB . PubMed: 24687851
  • Sabirzhanov B  et al. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci 34:10055-71 (2014). Mouse . PubMed: 25057207
  • Mamouni K  et al. RhoB promotes ?H2AX dephosphorylation and DNA double-strand break repair. Mol Cell Biol 34:3144-55 (2014). PubMed: 24912678
  • Castillo J  et al. Genomic and proteomic dissection and characterization of the human sperm chromatin. Mol Hum Reprod 20:1041-53 (2014). PubMed: 25193639
  • Katsogiannou M  et al. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Mol Cell Proteomics 13:3585-601 (2014). WB . PubMed: 25277244
  • Henriksson S  et al. The scaffold protein WRAP53ß orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes Dev 28:2726-38 (2014). Human . PubMed: 25512560
  • Soldi M & Bonaldi T The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components. Mol Cell Proteomics 12:764-80 (2013). WB, ChIP . PubMed: 23319141
  • Castro-Vega LJ  et al. Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas. Carcinogenesis N/A:N/A (2013). Human . PubMed: 23358853
  • Mahen R  et al. A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei. PLoS One 8:e61893 (2013). WB, ICC/IF . PubMed: 23658700
  • Britton S  et al. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J Cell Biol 202:579-95 (2013). PubMed: 23897892
  • Seo J  et al. Genome-wide reorganization of histone H2AX toward particular fragile sites on cell activation. Nucleic Acids Res N/A:N/A (2013). WB, ChIP ; Human . PubMed: 24163101
  • Sparks A  et al. The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. Oncogene N/A:N/A (2013). Human . PubMed: 24121268
  • Cesare AJ  et al. The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell 51:141-55 (2013). Human . PubMed: 23850488
  • Brochier C  et al. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci 33:8621-32 (2013). Mouse . PubMed: 23678107
  • Floyd SR  et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature 498:246-50 (2013). PubMed: 23728299
  • Naito Y  et al. Recruitment of cyclin G2 to promyelocytic leukemia nuclear bodies promotes dephosphorylation of ?H2AX following treatment with ionizing radiation. Cell Cycle 12:1773-84 (2013). Mouse . PubMed: 23656780
  • Sabirzhanov B  et al. Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. J Neurochem 123:542-54 (2012). PubMed: 22909049
  • Li Z  et al. Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell 151:1608-16 (2012). ChIP ; Mouse . PubMed: 23260146
  • Hayashi MT  et al. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nat Struct Mol Biol 19:387-94 (2012). Human . PubMed: 22407014
  • Fiedler J  et al. MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 124:720-30 (2011). WB, IHC-Fr ; Mouse . PubMed: 21788589
  • Mehrotra PV  et al. DNA Repair Factor APLF Is a Histone Chaperone. Mol Cell 41:46-55 (2011). ICC/IF ; Human . PubMed: 21211722
  • Iwamori N  et al. The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility. Biol Reprod 84:1225-34 (2011). PubMed: 21293030
  • Wu M  et al. Selenium compounds activate early barriers of tumorigenesis. J Biol Chem 285:12055-62 (2010). ICC/IF ; Human . PubMed: 20157118
  • Rimmelé P  et al. Spi-1/PU.1 oncogene accelerates DNA replication fork elongation and promotes genetic instability in the absence of DNA breakage. Cancer Res 70:6757-66 (2010). WB . PubMed: 20660370
  • Nashun B  et al. Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice. Development 137:3785-94 (2010). WB, IHC, ICC/IF ; Mouse . PubMed: 20943707
  • Yang X  et al. Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. J Proteome Res 9:1402-15 (2010). WB, ICC/IF ; Human . PubMed: 20000738
  • Dimitrova N & de Lange T Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Mol Cell Biol 29:5552-63 (2009). WB ; Mouse . PubMed: 19667071
  • Lee JH  et al. Chromatin analysis of occluded genes. Hum Mol Genet 18:2567-74 (2009). ChIP ; Human . PubMed: 19380460
  • Cook PJ  et al. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 458:591-6 (2009). PubMed: 19234442
  • Dawson MA  et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461:819-22 (2009). WB ; Human . PubMed: 19783980
  • Tjeertes JV  et al. Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J 28:1878-89 (2009). WB ; Human . PubMed: 19407812
  • Ziegler-Birling C  et al. Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage. Int J Dev Biol 53:1003-11 (2009). Mouse . PubMed: 19598117
  • Guervilly JH  et al. Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia. Hum Mol Genet 17:679-89 (2008). PubMed: 18029388
  • Mu W  et al. An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol 28:6439-51 (2008). WB ; Mouse . PubMed: 18710940
  • Dimitrova N & de Lange T MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev 20:3238-43 (2006). PubMed: 17158742
  • Cowell IG  et al. Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated. Biochem Pharmacol 71:13-20 (2005). PubMed: 16293233

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