Anti-Histone acetyltransferase MYST3抗体(ab41718)

概述

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, 1% BSA, PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab41718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 2 - 6 µg/ml. Detects a band of approximately 220 kDa (predicted molecular weight: 222 kDa). A 50kDa unknown band can also be detected.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.
    • 疾病相关Note=Chromosomal aberrations involving MYST3 may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
      Note=A chromosomal aberration involving MYST3 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a MYST3-ASXL2 fusion protein.
    • 序列相似性Belongs to the MYST (SAS/MOZ) family.
      Contains 1 C2HC-type zinc finger.
      Contains 1 H15 (linker histone H1/H5 globular) domain.
      Contains 2 PHD-type zinc fingers.
    • 结构域The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
    • 翻译后修饰Autoacetylated.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus. Partially concentrated in subnuclear foci distinct from PML bodies, and excluded from the nucleoli.
    • Information by UniProt
    • 数据库链接
    • 别名
      • HAT 3 antibody
      • Histone acetyltransferase MYST3 antibody
      • Monocytic leukemia zinc finger protein antibody
      • MOZ antibody
      • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 antibody
      • MYST histone acetyltransferase (monocytic leukemia) 3 antibody
      • MYST protein 3 antibody
      • MYST-3 antibody
      • MYST3 antibody
      • MYST3_HUMAN antibody
      • OTTHUMP00000197392 antibody
      • OTTHUMP00000197394 antibody
      • OTTHUMP00000225722 antibody
      • Runt related transcription factor binding protein 2 antibody
      • Runt-related transcription factor-binding protein 2 antibody
      • RUNXBP2 antibody
      • SAS2 antibody
      • SAS2 and TIP60 protein 3 antibody
      • TIP60 protein 3 antibody
      • YBF2/SAS3 antibody
      • ZC2HC6A antibody
      • Zinc finger protein 220 antibody
      • ZNF220 antibody
      see all

    Anti-Histone acetyltransferase MYST3 antibody (ab41718)参考文献

    This product has been referenced in:
    • Paggetti J  et al. Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells. Oncogene 29:5019-31 (2010). WB ; Human . Read more (PubMed: 20581860) »

    See 1 Publication for this product

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