概述

  • 产品名称Anti-HIST1H2BJ抗体
  • 描述
    兔多克隆抗体to HIST1H2BJ
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human HIST1H2BJ aa 60-90 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).
    Database link: P06899

  • 阳性对照
    • CEM cell line lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab107806 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab107806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 14 kDa.

靶标

  • 功能Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
  • 序列相似性Belongs to the histone H2B family.
  • 翻译后修饰Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II.
    Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • 细胞定位Nucleus. Chromosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • H2B histone family member R antibody
    • H2B/r antibody
    • H2B1J_HUMAN antibody
    • H2BFR antibody
    • HIST1H2BJ antibody
    • Histone 1 H2bj antibody
    • Histone cluster 1 H2bj antibody
    • Histone H2B type 1-J antibody
    • Histone H2B.1 antibody
    • Histone H2B.r antibody
    see all

Anti-HIST1H2BJ antibody 图像

  • Anti-HIST1H2BJ antibody (ab107806) at 1/100 dilution + CEM cell line lysate at 35 µg

    Predicted band size : 14 kDa

Anti-HIST1H2BJ antibody (ab107806)参考文献

ab107806 has not yet been referenced specifically in any publications.

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