概述

  • 产品名称Anti-HIST1H2AK抗体
    参阅全部 HIST1H2AK 一抗
  • 描述
    兔多克隆抗体to HIST1H2AK
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide within Human HIST1H2AK aa 1-30 (N terminal) (unmodified ) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary. Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 1-30 of Human HIST1H2AK (NP_003501.1).
    Sequence:

    SGRGKQGGK ARAKAKTRSS RAGLQFPVGR V


    Database link: P0C0S8

  • 阳性对照
    • K562 cell line lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明This antibody is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab103952 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 14 kDa.

靶标

  • 功能Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • 序列相似性Belongs to the histone H2A family.
  • 翻译后修饰The chromatin-associated form is phosphorylated on Thr-121 during mitosis.
    Deiminated on Arg-4 in granulocytes upon calcium entry.
    Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.
    Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.
    Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • 细胞定位Nucleus. Chromosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • H2A histone family, member P antibody
    • H2A.1 antibody
    • H2A.1b antibody
    • H2A/n antibody
    • H2A/p antibody
    • H2A1_HUMAN antibody
    • H2AF antibody
    • H2AFC antibody
    • H2AFD ANDHIST1H2AL antibody
    • H2AFD antibody
    • H2AFI antibody
    • H2AFN ANDHIST1H2AG antibody
    • H2AFN antibody
    • H2AFP antibody
    • HIST1H2AI antibody
    • HIST1H2AJ antibody
    • HIST1H2AK antibody
    • HIST1H2AL antibody
    • HIST1H2AM antibody
    • Histone 1, H2ag antibody
    • Histone cluster 1, H2ag antibody
    • Histone H2A type 1 antibody
    • Histone H2A.c/d/i/n/p antibody
    • Histone H2A/p antibody
    • pH2A/f antibody
    see all

Anti-HIST1H2AK antibody 图像

  • Anti-HIST1H2AK antibody (ab103952) at 1/100 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 14 kDa

Anti-HIST1H2AK antibody (ab103952)参考文献

ab103952 has not yet been referenced specifically in any publications.

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