Anti-HIRA (phospho T555)抗体(ab61095)

概述

  • 产品名称Anti-HIRA (phospho T555)抗体
    参阅全部 HIRA 一抗
  • 描述
    兔多克隆抗体to HIRA (phospho T555)
  • 特异性ab61095 detects endogenous levels of HIRA only when phosphorylated at threonine 555.
  • 经测试应用适用于: ICC/IF, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthesized phosphopeptide derived from human HIRA around the phosphorylation site of threonine 555 (L-T-TP-P-S).

  • 阳性对照
    • HeLa cells

性能

应用

Our Abpromise guarantee covers the use of ab61095 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/500 - 1/1000.
ELISA 1/5000.

靶标

  • 功能Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
  • 组织特异性Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.
  • 序列相似性Belongs to the WD repeat HIR1 family.
    Contains 8 WD repeats.
  • 发展阶段Expressed during embryogenesis.
  • 翻译后修饰Sumoylated.
    Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.
  • 细胞定位Nucleus. Nucleus > PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DGCR1 antibody
    • DiGeorge critical region gene 1 antibody
    • HIR antibody
    • HIR histone cell cycle regulation defective homolog A antibody
    • HIRA antibody
    • HIRA protein antibody
    • HIRA_HUMAN antibody
    • Histone cell cycle regulator antibody
    • Protein HIRA antibody
    • TUP 1 antibody
    • TUP1 like enhancer of split protein 1 antibody
    • TUP1-like enhancer of split protein 1 antibody
    • TUPLE1 antibody
    see all

Anti-HIRA (phospho T555) antibody 图像

  • Immunofluorescence analysis of HeLa cells, using ab61095 at a 1/500 dilution, minus immunising peptide (left image) and plus immunising peptide (right image).

Anti-HIRA (phospho T555) antibody (ab61095)参考文献

ab61095 has not yet been referenced specifically in any publications.

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