概述

  • 产品名称Anti-HIRA抗体
    参阅全部 HIRA 一抗
  • 描述
    兔多克隆抗体to HIRA
  • 特异性Detects endogenous levels of total HIRA protein
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from an internal region of Human HIRA.

  • 阳性对照
    • Human tonsil tissue.

性能

应用

Our Abpromise guarantee covers the use of ab111196 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
  • 组织特异性Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.
  • 序列相似性Belongs to the WD repeat HIR1 family.
    Contains 8 WD repeats.
  • 发展阶段Expressed during embryogenesis.
  • 翻译后修饰Sumoylated.
    Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.
  • 细胞定位Nucleus. Nucleus > PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DGCR1 antibody
    • DiGeorge critical region gene 1 antibody
    • HIR antibody
    • HIR histone cell cycle regulation defective homolog A antibody
    • HIRA antibody
    • HIRA protein antibody
    • HIRA_HUMAN antibody
    • Histone cell cycle regulator antibody
    • Protein HIRA antibody
    • TUP 1 antibody
    • TUP1 like enhancer of split protein 1 antibody
    • TUP1-like enhancer of split protein 1 antibody
    • TUPLE1 antibody
    see all

Anti-HIRA antibody 图像

  • ab111196 at 1/50 dilution staining HIRA in paraffin-embedded Human Tonsil tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-HIRA antibody (ab111196)参考文献

ab111196 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab111196.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"