Anti-HIRA抗体[374C6a] (ab70734)

概述

  • 产品名称Anti-HIRA抗体[374C6a]
    参阅全部 HIRA 一抗
  • 描述
    小鼠单克隆抗体[374C6a] to HIRA
  • 经测试应用适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment derived from internal sequence of human HIRA

  • 阳性对照
    • Recombinant human HIRA.

性能

应用

Our Abpromise guarantee covers the use of ab70734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 112 kDa.
Dot blot Use at an assay dependent dilution.

靶标

  • 功能Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
  • 组织特异性Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.
  • 序列相似性Belongs to the WD repeat HIR1 family.
    Contains 8 WD repeats.
  • 发展阶段Expressed during embryogenesis.
  • 翻译后修饰Sumoylated.
    Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.
  • 细胞定位Nucleus. Nucleus > PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DGCR1 antibody
    • DiGeorge critical region gene 1 antibody
    • HIR antibody
    • HIR histone cell cycle regulation defective homolog A antibody
    • HIRA antibody
    • HIRA protein antibody
    • HIRA_HUMAN antibody
    • Histone cell cycle regulator antibody
    • Protein HIRA antibody
    • TUP 1 antibody
    • TUP1 like enhancer of split protein 1 antibody
    • TUP1-like enhancer of split protein 1 antibody
    • TUPLE1 antibody
    see all

Anti-HIRA antibody [374C6a] 图像

Anti-HIRA antibody [374C6a] (ab70734)参考文献

ab70734 has not yet been referenced specifically in any publications.

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