概述

  • 产品名称Anti-HIPK1抗体
    参阅全部 HIPK1 一抗
  • 描述
    小鼠单克隆抗体to HIPK1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 330-430 of Human HIPK1

性能

应用

Our Abpromise guarantee covers the use of ab58136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.
    • 组织特异性Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.
    • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
      Contains 1 protein kinase domain.
    • 翻译后修饰Autophosphorylated. Phosphorylated and activated by JNK1.
    • 细胞定位Nucleus. Cytoplasm. Predominantly nuclear.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Hipk 1 antibody
      • Hipk1 antibody
      • HIPK1_HUMAN antibody
      • Homeodomain interacting protein kinase 1 antibody
      • Homeodomain interacting protein kinase 1 like protein antibody
      • Homeodomain-interacting protein kinase 1 antibody
      • Myak antibody
      • Nbak 2 antibody
      • Nbak2 antibody
      • Nuclear body associated kinase 2 antibody
      • Nuclear body associated kinase 2b antibody
      see all

    Anti-HIPK1 antibody 图像

    • HIPK1 antibody (ab58136) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human salivary gland.
    • Western blot against tagged recombinant protein immunogen using ab58136 HIPK1 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

    Anti-HIPK1 antibody (ab58136)参考文献

    This product has been referenced in:
    • Park BW  et al. Homeodomain-interacting Protein Kinase 1 (HIPK1) Expression in Breast Cancer Tissues. Jpn J Clin Oncol 42:1138-45 (2012). IHC-P . Read more (PubMed: 23071292) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"