概述

  • 产品名称
  • 描述
    兔多克隆抗体to HIP1R
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Synthetic peptide:

    QDHQLDKKDGIYPAQLVNY

    , corresponding to N terminal amino acids 264-282 of Human HIP1R

  • 阳性对照
    • P2 microsomal fraction from embryonic rat brain. Rat brain extract.

性能

应用

Our Abpromise guarantee covers the use of ab79162 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/2000. Detects a band of approximately 116 kDa (predicted molecular weight: 119 kDa).

靶标

  • 功能
    Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
  • 组织特异性
    Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
  • 序列相似性
    Belongs to the SLA2 family.
    Contains 1 ENTH (epsin N-terminal homology) domain.
    Contains 1 I/LWEQ domain.
  • 结构域
    Binds F-actin via the talin-like I/LWEQ domain.
  • 细胞定位
    Cytoplasm > perinuclear region. Endomembrane system. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ14000 antibody
    • FLJ27022 antibody
    • HIP-12 antibody
    • Hip1 related antibody
    • HIP1-related protein antibody
    • HIP12 antibody
    • HIP1R antibody
    • HIP1R_HUMAN antibody
    • HIP3 antibody
    • Huntingtin Interacting Protein 1 Related antibody
    • Huntingtin interacting protein 12 antibody
    • Huntingtin-interacting protein 1-related protein antibody
    • Huntingtin-interacting protein 12 antibody
    • ILWEQ antibody
    • KIAA0655 antibody
    • MGC47513 antibody
    see all

图片

实验方案

文献

ab79162 has not yet been referenced specifically in any publications.

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