概述

  • 产品名称Anti-HHV8抗体[LN35]
  • 描述
    大鼠单克隆抗体[LN35] to HHV8
  • 特异性HHV 8 is the likely etiological agent of Kaposi’s sarcoma (KS). HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity.
  • 经测试应用适用于: ICC/IF, IHC-P, IHC-Frmore details
  • 种属反应性
    Human Herpes virus 8
  • 免疫原

    Recombinant protein corresponding to the latent nuclear antigen 1 molecule of HHV 8.

  • 表位Located within the ORF-73 region.
  • 阳性对照
    • Kaposi’s sarcoma.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, Tissue culture supernatant
  • Concentration information loading...
  • 纯度IgG fraction
  • 克隆单克隆
  • 克隆编号LN35
  • 同种型IgG2c
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab4103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration. PubMed: 24250827
IHC-P 1/25 - 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. ABC method.
IHC-Fr 1/25 - 1/50. ABC method.

靶标

  • 相关性HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.
  • 别名
    • HHV 8 antibody
    • Human Herpes Virus 8 antibody
    • Human herpesvirus 8 antibody
    • Kaposi's sarcoma associated herpes virus antibody
    • KSHV antibody
    see all

Anti-HHV8 antibody [LN35] 图像

  • Cultured cells infected with HHV8, stained with HHV8 using ABC and DAB chromogen.

Anti-HHV8 antibody [LN35] (ab4103)参考文献

This product has been referenced in:
  • El Hajj H  et al. Combination of arsenic and interferon-a inhibits expression of KSHV latent transcripts and synergistically improves survival of mice with primary effusion lymphomas. PLoS One 8:e79474 (2013). ICC/IF . Read more (PubMed: 24250827) »
  • Loddenkemper C  et al. [The morphologic variants of KSHV/HHV 8-associated lymphoproliferations.] Pathologe : (2006). Read more (PubMed: 17160657) »

See all 2 Publications for this product

Product Wall


The specific epitope of ab4103 is near the C terminus of the ORF-73 region within HHV8. Below is more information about specific recombinant proteins that this antibody recognizes.

GST-C14, GST-C17, GST-C7, and TH-C14;

GST-C14 co...

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Thank you for contacting us.

We do not have clone 13B10 in catalogue like the Leica microsystem. We however have antibody that is specific to HHV8- latent nuclear antigen that can quoted to customer;

http://www.abcam.com/hhv8-antibody...

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The laboratory responded that the epitope for ab4103 is near the C terminus of ORF 73 within HHV8.

Thank you for your telephone enquiry yesterday afternoon. As requested, here is a list of all our antibodies for detection of HHV8 virus. I can recommend to review the online datasheets for further information. ab4103 Rat monoclonal Anti...

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Thank you for your enquiry and your patience in awaiting a response. HHV8 is human herpes virus and was tested only on human infected tissue. It was not tested for any other virus infected animal tissues. If you have any further questions then please d...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"