概述

  • 产品名称Anti-HEXIM1抗体
    参阅全部 HEXIM1 一抗
  • 描述
    羊多克隆抗体to HEXIM1
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein (Human) with 6x His tag

性能

应用

Our Abpromise guarantee covers the use of ab28016 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 41 kDa).
IP Use at an assay dependent dilution.

靶标

  • 功能Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
  • 组织特异性Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
  • 序列相似性Belongs to the HEXIM family.
  • 结构域The coiled-coil domain mediates oligomerization.
  • 细胞定位Nucleus. Cytoplasm. Binds alpha-importin and is mostly nuclear.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cardiac lineage protein 1 antibody
    • CLP 1 antibody
    • CLP1 antibody
    • EDG 1 antibody
    • EDG1 antibody
    • Estrogen down-regulated gene 1 protein antibody
    • FLJ13562 antibody
    • Hexamethylene bis acetamide inducible 1 antibody
    • Hexamethylene bis acetamide inducible protein antibody
    • Hexamethylene bis acetamide inducible transcript 1 antibody
    • Hexamethylene bis-acetamide-inducible protein 1 antibody
    • HEXI1_HUMAN antibody
    • HEXIM 1 antibody
    • Hexim1 antibody
    • HEXIM1 protein antibody
    • HIS 1 antibody
    • HIS1 antibody
    • HMBA inducible antibody
    • MAQ 1 antibody
    • MAQ1 antibody
    • Menage a quatre 1 antibody
    • Menage a quatre protein 1 antibody
    • Protein HEXIM1 antibody
    see all

Anti-HEXIM1 antibody 图像

  • All lanes : Anti-HEXIM1 antibody (ab28016) at 1/1000 dilution

    Lane 1 : recombinant 6x His tagged HEXIM1 protein
    Lane 2 : Hela whole cell lysate
    Lane 3 : Hela cell nuclear lysate

    Secondary
    donkey anti-sheep peroxidase conjugate at 1/20000 dilution

    Predicted band size : 41 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)

Anti-HEXIM1 antibody (ab28016)参考文献

This product has been referenced in:
  • Safronova OS  et al. Acute hypoxia affects P-TEFb through HDAC3 and HEXIM1-dependent mechanism to promote gene-specific transcriptional repression. Nucleic Acids Res 42:8954-69 (2014). IP ; Human . Read more (PubMed: 25056306) »
  • Natarajan M  et al. Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cells. J Biol Chem 285:17338-47 (2010). WB ; Human . Read more (PubMed: 20368329) »

See all 6 Publications for this product

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