概述

  • 产品名称Anti-HEXA抗体
    参阅全部 HEXA 一抗
  • 描述
    兔多克隆抗体to HEXA
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the central region of Human HEXA (NP_000511.2).

  • 阳性对照
    • HepG2 cell line lysates

性能

应用

Our Abpromise guarantee covers the use of ab93111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 61 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.
    • 疾病相关Defects in HEXA are the cause of GM2-gangliosidosis type 1 (GM2G1) [MIM:272800]; also known as Tay-Sachs disease. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G1 is characterized by GM2 gangliosides accumulation in the absence of HEXA activity, leading to neurodegeneration and, in the infantile form, death in early childhood. GM2G1 has an increased incidence among Ashkenazi Jews and French Canadians in eastern Quebec. It exists in several forms: infantile (most common and most severe), juvenile and adult (late onset).
    • 序列相似性Belongs to the glycosyl hydrolase 20 family.
    • 翻译后修饰N-linked glycan at Asn-115 consists of Man(3)-GlcNAc(2).
    • 细胞定位Lysosome.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Beta hexosaminidase alpha chain precursor antibody
      • Beta hexosaminidase subunit alpha antibody
      • Beta N acetylhexosaminidase antibody
      • Beta N acetylhexosaminidase subunit alpha antibody
      • Beta-hexosaminidase A antibody
      • Beta-hexosaminidase subunit alpha antibody
      • Beta-N-acetylhexosaminidase subunit alpha antibody
      • Hexa antibody
      • HEXA_HUMAN antibody
      • Hexosaminidase A (alpha polypeptide) antibody
      • Hexosaminidase A alpha polypeptide antibody
      • Hexosaminidase A antibody
      • Hexosaminidase subunit A antibody
      • MGC99608 antibody
      • N acetyl beta glucosaminidase antibody
      • N acetyl beta glucosaminidase subunit alpha antibody
      • N-acetyl-beta-glucosaminidase subunit alpha antibody
      • TSD antibody
      see all

    Anti-HEXA antibody 图像

    • Anti-HEXA antibody (ab93111) at 1/100 dilution + HepG2 cell line lysates at 35 µg

      Predicted band size : 61 kDa

    Anti-HEXA antibody (ab93111)参考文献

    ab93111 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"