概述

  • 产品名称Anti-Hepcidin抗体
    参阅全部 Hepcidin 一抗
  • 描述
    小鼠单克隆抗体to Hepcidin
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein corresponding to Human Hepcidin aa 25-85.
    Sequence:

    SVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCH RSKCGMCCKT

性能

应用

Our Abpromise guarantee covers the use of ab57611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen and may not recognize Hepcidin 25 but pro-hepcidin. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages.
      Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
    • 组织特异性Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.
    • 疾病相关Hemochromatosis 2B
    • 序列相似性Belongs to the hepcidin family.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Hamp antibody
      • HEPC antibody
      • HEPC_HUMAN antibody
      • Hepc20 antibody
      • Hepc25 antibody
      • Hepcidin-20 antibody
      • HFE2B antibody
      • LEAP-1 antibody
      • LEAP1 antibody
      • Liver-expressed antimicrobial peptide 1 antibody
      • PLTR antibody
      • Putative liver tumor regressor antibody
      see all

    Anti-Hepcidin antibody 图像

    • Hepcidin-25 antibody (ab57611) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human liver.
    • Western blot against tagged recombinant protein immunogen using ab57611 Hepcidin-25 antibody at 1ug/ml. Predicted band size of immunogen is 33 kDa

    Anti-Hepcidin antibody (ab57611)参考文献

    This product has been referenced in:
    • Li JJ  et al. Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis. Arterioscler Thromb Vasc Biol 32:1158-66 (2012). ICC/IF ; Mouse . Read more (PubMed: 22383698) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"