Anti-Hepatitis C Virus NS4抗体(ab20955)

概述

  • 产品名称
    Anti-Hepatitis C Virus NS4抗体
    参阅全部 Hepatitis C Virus NS4 一抗
  • 描述
    山羊多克隆抗体to丙型肝炎病毒NS4
  • 特异性
    Ab20955 recognises Hepatitis C Virus, NS4 Region.
  • 经测试应用
    适用于: ELISA, WB, Conjugationmore details
  • 免疫原

    Recombinant NS-4 (genotype 1a)

性能

应用

Our Abpromise guarantee covers the use of ab20955 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
Conjugation
  • 应用说明
    Conjugation: Use at an assay dependent dilution. ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 50 kDa. Dilution optimised using Chromogenic detection. May be used in place of neat antiserum in almost any appropriate antibody-based technique. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性
      NS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
    • 细胞定位
      Endoplasmic reticulum; multi-pass membrane protein.
    • 别名
      • HCV antibody
      • HCV NS4 antibody
      • Hepatitis C Virus nonstructural antigen 4 antibody
      • Non structural protein 4A antibody
      • Non structural protein 4B antibody
      • NS4A antibody
      • NS4B antibody
      • p27 antibody
      • p8 antibody
      see all

    实验方案

    文献

    ab20955 has not yet been referenced specifically in any publications.

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