Anti-Hepatitis C Virus NS4抗体[497] (ab19052)

概述

  • 产品名称Anti-Hepatitis C Virus NS4抗体[497]
    参阅全部 Hepatitis C Virus NS4 一抗
  • 描述
    小鼠单克隆抗体[497] to丙型肝炎病毒NS4
  • 特异性ab19052 reacts with synthetic NS4a Protein (1689a.a.-1735a.a.) and recombinant Chimeric HCV Polyprotein (60 kDa). No cross reaction with synthetic recombinant Capsid Protein C + Envelope Protein M (core) (1a.a.-142a.a.), synthetic Capsid Protein C (1a.a.-61a.a.), recombinant NS3 Protein (1252a.a.-1477a.a.) and synthetic NS3 Protein (1378a.a.-1458a.a.)
  • 经测试应用适用于: ELISA, WBmore details
  • 免疫原

    Recombinant full length protein (Purified recombinant Chimeric HCV Polyprotein, 555aa)

性能

应用

Our Abpromise guarantee covers the use of ab19052 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 0.5 µg/ml. Detects Recombinant Chimeric
    HCV Polyprotein at a band of approximately 60 kDa (predicted molecular weight: 60 kDa).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性NS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
    • 细胞定位Endoplasmic reticulum; multi-pass membrane protein.
    • 别名
      • HCV antibody
      • HCV NS4 antibody
      • Hepatitis C Virus nonstructural antigen 4 antibody
      • Non structural protein 4A antibody
      • Non structural protein 4B antibody
      • NS4A antibody
      • NS4B antibody
      • p27 antibody
      • p8 antibody
      see all

    Anti-Hepatitis C Virus NS4 antibody [497] (ab19052)参考文献

    ab19052 has not yet been referenced specifically in any publications.

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