Anti-Hepatitis C Virus NS3抗体(ab21124)

概述

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: 0.01M PBS, pH 7.2
  • Concentration information loading...
  • 纯度IgG fraction
  • 纯化说明Sodium sulfate precipitation & ion-exchange chromatography.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab21124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
ICC/IF Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 72 kDa.

靶标

  • 相关性HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins including NS3, and several non-structural proteins necessary for viral replication. The NS3 part of the polyprotein displays three enzymatic activities: serine protease, NTPase and RNA helicase. The NS3 serine proteinase (NS3P) is a non-structural hepatitis C protein responsible for proteolytic processing of other non-structural proteins; because of this, it is also the most extensively studied protein of the Hepatitis C genome. It is responsible for proteolytic processing of the entire downstream region of the HC polyprotein, catalyzing cleavage at the NS3/NS4a, NS4a/NS4b, NS4b/NS5a, and NS5a/NS5b sites to release the mature NS3, NS4a, NS4b, NS5a, and NS5b proteins.For proper function, NS3 requires NS4a as a cofactor, but, interestingly enough, NS3 also cleaves the NS4a protein. The molecular weight of the monomer NS3P is 70 kDa.
  • 细胞定位Endoplasmic reticulum membrane
  • 别名
    • Hepatitis C Virus NS3 antibody
    • NS3 antibody
    • NS3P antibody
    • p70 antibody
    • Serine protease/NTPase/helicase antibody
    see all

Anti-Hepatitis C Virus NS3 antibody (ab21124)参考文献

This product has been referenced in:
  • Quan H  et al. Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition. Oncogene N/A:N/A (2013). Read more (PubMed: 23770846) »
  • Kannan RP  et al. Hepatitis C virus infection causes cell cycle arrest at the level of initiation of mitosis. J Virol 85:7989-8001 (2011). WB . Read more (PubMed: 21680513) »

See all 4 Publications for this product

Product Wall

Thank you for your enquiry. Goat anti HCV NS3, ab21124, is a polyclonal antibody and therefore recognizes multiple epitopes. The immunogen is a recombinant protein representing the full-length NS3 sequence. It is likely that some of the epitopes r...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"