Anti-Hepatitis C Virus E2抗体[BDI167] (ab20852)

概述

  • 产品名称Anti-Hepatitis C Virus E2抗体[BDI167]
    参阅全部 Hepatitis C Virus E2 一抗
  • 描述
    小鼠单克隆抗体[BDI167] to丙型肝炎病毒E2
  • 经测试应用适用于: ELISA, ICC/IF, WBmore details
  • 种属反应性
    Reacts with Hepatitis C Virus. Not yet tested in other species.
  • 免疫原

    Recombinant full length HCV E2 protein, genotype 1b

  • 表位Epitope has not been determined.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: 10mM PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号BDI167
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab20852 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/20 - 1/200.
ICC/IF Use at an assay dependent dilution.
WB 1/20 - 1/200. Predicted molecular weight: 1 kDa. Dilution optimised using Chromogenic detection.

靶标

  • 相关性Hepatitis C E2 is a virus envelope glycoprotein which forms a heterodimer with the E1 protein. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.
  • 细胞定位Viral envelope protein.
  • 别名
    • Core protein antibody
    • E1 protein antibody
    • E2 protein antibody
    • Envelope glycoprotein E2 antibody
    • gp68 antibody
    • gp70 antibody
    • HCV E2 antibody
    • NS1 antibody
    • NS2 protein antibody
    • NS3 protease/helicase antibody
    • NS4A protein antibody
    • NS4B protein antibody
    • NS5A protein antibody
    • NS5B RNA dependent RNA polymerase antibody
    • P7 protein antibody
    • Polyprotein antibody
    see all

Anti-Hepatitis C Virus E2 antibody [BDI167] (ab20852)参考文献

This product has been referenced in:
  • Bisoffi M  et al. Rapid detection of human immunodeficiency virus types 1 and 2 by use of an improved piezoelectric biosensor. J Clin Microbiol 51:1685-91 (2013). Read more (PubMed: 23515541) »
  • Ivanov AV  et al. Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-Dependent and Independent Mechanisms in HUH7 Cells. PLoS One 6:e24957 (2011). WB . Read more (PubMed: 21931870) »

See all 2 Publications for this product

Product Wall

I am very pleased to hear you would like to test ab20852 in FC. This code will give you $424 off your next order before the expiration date. To redeem this offer, please submit an Abreview for FC and include this code in the “Additional Comments&...

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Thank you very much for your interest in ab20852 and ab21306.

To our knowledge, ab20852 and ab21306 havenot been tested in flow cytometry (FC). Therefore, I can offer a discount off a future purchase if you buy ab20852 and ab21306 now, test ...

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Thank you for contacting us.

Following your enquiry I have checked all our HAV, HCV and Parvovirus B19 antibodies and doublechecked with the originators of these if the antibodies would detect intact virions. Thank you for your patience whil...

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Thank you for your enquiry. Our on-line datasheets are updated as soon as any new information is brought to our attention. Unfortunately, we do not have any feedback from customers regarding genotype 2a cross-reactivity for this product. If you...

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Thank you for your patience in this matter. I have received an answer from the originator of ab20852 (Hepatitis C Virus E2 antibody). The "genotype 1a" information was an error that was discovered last year and had been corrected. The information ...

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Thank you for your enquiry. For ab20852, the antibody recognizes genotype 1b and the immunogen used to generate the antibody was recombinant full length HCV E2 protein, genotype 1b. The epitope has not been determined and the antibody has been tested f...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"