Anti-Hepatitis C Virus E2抗体(ab54556)


  • 产品名称Anti-Hepatitis C Virus E2抗体
    参阅全部 Hepatitis C Virus E2 一抗
  • 描述
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Hepatitis C Virus
  • 免疫原

    A synthetic peptide corresponding to N-terminal residues of Hepatitis C Virus E2



Our Abpromise guarantee covers the use of ab54556 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.


  • 相关性Hepatitis C E2 is a virus envelope glycoprotein which forms a heterodimer with the E1 protein. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.
  • 细胞定位Viral envelope protein.
  • 数据库链接
    • 别名
      • Core protein antibody
      • E1 protein antibody
      • E2 protein antibody
      • Envelope glycoprotein E2 antibody
      • gp68 antibody
      • gp70 antibody
      • HCV E2 antibody
      • NS1 antibody
      • NS2 protein antibody
      • NS3 protease/helicase antibody
      • NS4A protein antibody
      • NS4B protein antibody
      • NS5A protein antibody
      • NS5B RNA dependent RNA polymerase antibody
      • P7 protein antibody
      • Polyprotein antibody
      see all

    Anti-Hepatitis C Virus E2 antibody (ab54556)参考文献

    ab54556 has not yet been referenced specifically in any publications.

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    This antibody hs been tested against E2 protein from HCV genotype 1A. It works well

    I hope this information is helpful to you. Please do not hesitate to contact us if you need...

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    Thank you for contacting us and your interest in our products.

    The immunogen sequence used to raise the anti-Hepatitis C Virus E2 antibody (ab54556) is proprietary information. However, in order to aid your research I am able to share it wit...

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    Thank you for contacting us.

    Following your enquiry I have checked all our HAV, HCV and Parvovirus B19 antibodies and doublechecked with the originators of these if the antibodies would detect intact virions. Thank you for your patience whil...

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    Thank you for your inquiry. I can confirm that these antibodies are raised against Hepatitis C Virus, genotype: 1B. They were never testedwith genotype 2A and might therefore not be suitable for genotype 2A. I am sorry that I could not provide you with...

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