Anti-Hepatitis C Virus E1抗体(ab54555)

概述

  • 产品名称Anti-Hepatitis C Virus E1抗体
    参阅全部 Hepatitis C Virus E1 一抗
  • 描述
    兔多克隆抗体to丙型肝炎病毒E1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Hepatitis C Virus
  • 免疫原

    Synthetic peptide corresponding to N-terminal residues of Hepatitis C Virus E1

性能

应用

Our Abpromise guarantee covers the use of ab54555 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

靶标

  • 相关性Envelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.
  • 细胞定位Endoplasmic reticulum membrane; Single-pass type I membrane protein
  • 数据库链接
    • 别名
      • E1 protein antibody
      • Envelope glycoprotein E1 antibody
      • Gp32 antibody
      • Gp35 antibody
      • HCV E1 antibody
      • HCV envelope glycoprotein E1 antibody
      • Hepatitis C virus envelope glycoprotein E1 antibody
      see all

    Anti-Hepatitis C Virus E1 antibody (ab54555)参考文献

    ab54555 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your inquiry.

    I can confirm that the 1b strain of the Hepatitis C E1 protein was used as immunogen.

    We know that ab54555 does notrecognize genotype 1a. Other possible cross reactivates were not experimentally tested. <...

    Read More

    Thank you for contacting us.

    Following your enquiry I have checked all our HAV, HCV and Parvovirus B19 antibodies and doublechecked with the originators of these if the antibodies would detect intact virions. Thank you for your patience whil...

    Read More

    Thank you for your inquiry. I can confirm that these antibodies are raised against Hepatitis C Virus, genotype: 1B. They were never testedwith genotype 2A and might therefore not be suitable for genotype 2A. I am sorry that I could not provide you with...

    Read More

    Thank you for contacting us. The 1b strain of  the Hepatitis C E1 protein used for immunogen in this product. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"