Anti-Hepatitis C Virus E1抗体(ab110972)

概述

  • 产品名称Anti-Hepatitis C Virus E1抗体
  • 描述
    山羊多克隆抗体to丙型肝炎病毒E1
  • 经测试应用适用于: ELISA, WB, ICC/IFmore details
  • 种属反应性
    与反应: Hepatitis C Virus
  • 免疫原

    Recombinant Hepatitis C Virus E1 (genotype 1a).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.1% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • 纯度Ion Exchange Chromatography
  • 纯化说明ab110972 is >95% pure by Sodium sulfate precipitation and ion exchange chromatography.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab110972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution. Reacts with genotype 1a.
WB Use at an assay dependent dilution. Predicted molecular weight: 23 kDa. Reacts with genotypes 1b and 2a.
ICC/IF Use at an assay dependent dilution. Reacts with genotype 1b, but does not react with genotype 2a.

靶标

  • 相关性Envelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells.
  • 数据库链接
    • 别名
      • E1 envelope glycoprotein antibody
      • HCV envelope glycoprotein antibody
      • Hepatitis C Virus envelope glycoprotein antibody

    Anti-Hepatitis C Virus E1 antibody (ab110972)参考文献

    ab110972 has not yet been referenced specifically in any publications.

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