Anti-Hepatitis C Virus Core Antigen抗体(ab58713)


  • 产品名称Anti-Hepatitis C Virus Core Antigen抗体
    参阅全部 Hepatitis C Virus Core Antigen 一抗
  • 描述
    兔多克隆抗体to丙型肝炎病毒Core Antigen
  • 经测试应用适用于: WB, ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Hepatitis C virus
  • 免疫原

    Synthetic peptide corresponding to N-terminal residues of Hepatitis C virus core protein.



Our Abpromise guarantee covers the use of ab58713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent concentration.
ICC/IF 1/200.


  • 相关性The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • 细胞定位Endoplasmic reticulum
  • 数据库链接
    • 别名
      • Core protein p21 antibody
      • HCV core antigen antibody
      • HCV core protein antibody
      • Hepatitis C Virus core protein antibody

    Anti-Hepatitis C Virus Core Antigen antibody 图像

    • ab58713 staining Hepatitis C Virus Core Antigen in the Huh-7 hepatocyte cell line from Human liver by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with methanol/acetone (1:1) and blocked with 5% BSA for 1 hour at 25°C. Samples were incubated with primary antibody (1/200 in PBS + 0.5% BSA) for 16 hours at 4°C. An FITC-conjugated goat anti-rabbit IgG polyclonal (1/50) was used as the secondary antibody.

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    Anti-Hepatitis C Virus Core Antigen antibody (ab58713)参考文献

    This product has been referenced in:
    • Granato M  et al. HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2. Sci Rep 6:30649 (2016). WB ; Human . Read more (PubMed: 27476557) »

    See 1 Publication for this product

    Product Wall

    Application Immunocytochemistry/ Immunofluorescence
    Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Sample Human Cell (human hepatocytes (Huh-7 cells))
    Specification human hepatocytes (Huh-7 cells)
    Permeabilization No
    Fixative 1:1 Methanol-acetone

    Nicole Corder

    Verified customer

    提交于 Jun 19 2014

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