概述
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产品名称Anti-Hepatitis C Virus Core Antigen抗体[11-B3]
参阅全部 Hepatitis C Virus Core Antigen 一抗 -
描述小鼠单克隆抗体[11-B3] to丙型肝炎病毒Core Antigen
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经测试应用适用于: IHC-Fr, ELISA, WBmore details
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种属反应性HCV core antigen.
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免疫原
Recombinant full length HCV core from 1B strain.
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表位Amino acids 70-90.
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常规说明Mouse monoclonal [11-B3] to Hepatitis C Virus Core Antigen (ab18929) stains primarily cytoplasmic; mainly in the perinuclear area.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: 0.01% Sodium Azide
Constituents: PBS, pH 7.2 -
Concentration information loading... -
纯度Protein G purified
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克隆单克隆
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克隆编号11-B3
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同种型IgG1
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab18929 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr | 1/20. | |
| ELISA | Use at an assay dependent concentration. | |
| WB | 1/1000. |
靶标
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相关性The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
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细胞定位Endoplasmic reticulum
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别名
- Core protein p21 antibody
- HCV core antigen antibody
- HCV core protein antibody
- Hepatitis C Virus core protein antibody
Anti-Hepatitis C Virus Core Antigen antibody [11-B3] (ab18929)参考文献
ab18929 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"