抗乙型肝炎病毒Surface Antigen (Ad/Ay)抗体(ab9193)

概述

  • 产品名称
    抗乙型肝炎病毒Surface Antigen (Ad/Ay)抗体
    参阅全部 Hepatitis B Virus Surface Antigen (Ad/Ay) 一抗
  • 描述
    马多克隆抗体to乙型肝炎病毒Surface Antigen (Ad/Ay)
  • 宿主
    Horse
  • 特异性
    This antibody is specific for Hepatitis B surface antigen
  • 经测试应用
    适用于: ELISA, IP, WBmore details
  • 种属反应性
    This antibody does not react with human serum proteins
  • 免疫原

    Immunization of horses with highly purified Ad/Ay antigen.

性能

应用

Our Abpromise guarantee covers the use of ab9193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
IP Use at an assay dependent concentration. PubMed: 20089655
WB 1/1000. PubMed: 19740987

靶标

  • 相关性
    Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase. Hepatitis B infection is normally diagnosed from serological tests that detect HBsAg but as the disease progresses this antigen may no longer be present in the blood and tests for HBcAg are used. If HBsAg can be detected in the blood for longer than six months, chronic hepatitis B is diagnosed. The antigenic determinant of the protein moiety of the HBsAg determines specific characteristics of different serotypes and provides the basis of immunodetection. HBsAg has antigenic heterogeneity, specifically, two pairs of sub specific determinants, d/y and w/r allow the following combinations: adw, ayw, adr, ayr.
  • 细胞定位
    Virion membrane
  • 别名
    • HBsAg antibody
    • HBV major surface antigen antibody
    • HBV surface antigen antibody
    • Hepatitis B Virus major surface antigen antibody
    • Major surface antigen antibody
    • S antibody
    see all

文献

This product has been referenced in:
  • Wang L  et al. A new model mimicking persistent HBV e antigen-negative infection using covalently closed circular DNA in immunocompetent mice. PLoS One 12:e0175992 (2017). IHC-P ; Mouse . Read more (PubMed: 28426720) »
  • Li J  et al. Unusual Features of Sodium Taurocholate Cotransporting Polypeptide as a Hepatitis B Virus Receptor. J Virol 90:8302-13 (2016). Read more (PubMed: 27384660) »

See all 9 Publications for this product

客户评价及客户问答

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Immunocytochemistry/ Immunofluorescence
Sample
Human Cell (Huh7 Human Hepatoma Cells)
Specification
Huh7 Human Hepatoma Cells
Fixative
Paraformaldehyde
Permeabilization
Yes - 0.1% Saponin
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提交于 Mar 22 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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