The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. Predicted molecular weight: 57 kDa.
Use at an assay dependent dilution.
功能Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
组织特异性Expressed predominantly in liver. Also present in plasma.
疾病相关Thrombophilia due to heparin cofactor 2 deficiency
序列相似性Belongs to the serpin family.
结构域The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
翻译后修饰Phosphorylation sites are present in the extracellular medium.