Anti-Heparin Cofactor II抗体[74E5] (ab51051)

概述

  • 产品名称Anti-Heparin Cofactor II抗体[74E5]
    参阅全部 Heparin Cofactor II 一抗
  • 描述
    小鼠单克隆抗体[74E5] to Heparin Cofactor II
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native Heparin Cofactor II (purified) from Human plasma

  • 阳性对照
    • Human plasma

性能

应用

Our Abpromise guarantee covers the use of ab51051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000. Predicted molecular weight: 57 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
    Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
  • 组织特异性Expressed predominantly in liver. Also present in plasma.
  • 疾病相关Thrombophilia due to heparin cofactor 2 deficiency
  • 序列相似性Belongs to the serpin family.
  • 结构域The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
  • 翻译后修饰Phosphorylation sites are present in the extracellular medium.
  • Information by UniProt
  • 数据库链接
  • 别名
    • D22S673 antibody
    • HC II antibody
    • HC-II antibody
    • HC2 antibody
    • HCF2 antibody
    • HEP2_HUMAN antibody
    • Heparin cofactor 2 antibody
    • Heparin cofactor II antibody
    • HLS2 antibody
    • Leuserpin 2 antibody
    • LS2 antibody
    • Protease inhibitor leuserpin 2 antibody
    • Protease inhibitor leuserpin-2 antibody
    • serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 antibody
    • Serpin D1 antibody
    • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 antibody
    • SERPIND1 antibody
    • THPH10 antibody
    see all

Anti-Heparin Cofactor II antibody [74E5] 图像

  • All lanes : Anti-Heparin Cofactor II antibody [74E5] (ab51051) at 1/2000 dilution

    Lane 1 : Heparin Cofactor II isolated from human plasma
    Lane 2 : Human plasma


    Predicted band size : 57 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)

Anti-Heparin Cofactor II antibody [74E5] (ab51051)参考文献

This product has been referenced in:
  • Acosta-Martin AE  et al. Quantitative mass spectrometry analysis using PAcIFIC for the identification of plasma diagnostic biomarkers for abdominal aortic aneurysm. PLoS One 6:e28698 (2011). WB ; Human . Read more (PubMed: 22163325) »

See 1 Publication for this product

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