Anti-Heparanase 1抗体(ab56781)

概述

  • 产品名称Anti-Heparanase 1抗体
    参阅全部 Heparanase 1 一抗
  • 描述
    小鼠单克隆抗体to Heparanase 1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: LILLGSPKLR TLARGLSPAY LRFGGTKTDF LIFDPKKEST FEERSYWQSQ VNQDICKYGS IPPDVEEKLR LEWPYQEQLL LREHYQKKFK NSTYSRSSV, corresponding to amino acids 72-171 of Human Heparanase 1

性能

应用

Our Abpromise guarantee covers the use of ab56781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti-cancer therapies.
    • 组织特异性Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues.
    • 序列相似性Belongs to the glycosyl hydrolase 79 family.
    • 翻译后修饰Proteolytically processed. The cleavage of the 65 kDa form leads to the generation of a linker peptide, 8 kDa and 50 kDa product. The active form, the 8/50 kDa heterodimer, is resistant to degradation. Complete removal of the linker peptide appears to be a prerequisite to the complete activation of the enzyme.
      N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility.
    • 细胞定位Lysosome membrane. Secreted. Secreted, internalised and transferred to late endosomes/lysosomes as a proheparanase. In lysosomes, it is processed into the active form, the heparanase. The uptake or internalisation of proheparanase is mediated by HSPGs. Heparin appears to be a competitor and retain proheparanase in the extracellular medium.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Endo glucoronidase antibody
      • Endo-glucoronidase antibody
      • HEP antibody
      • Heparanase 50 kDa subunit antibody
      • Heparanase antibody
      • Heparanase-1 antibody
      • Heparanase1 antibody
      • Hpa 1 antibody
      • HPA antibody
      • Hpa1 antibody
      • HPR 1 antibody
      • HPR1 antibody
      • HPSE 1 antibody
      • HPSE antibody
      • HPSE_HUMAN antibody
      • HPSE1 antibody
      • HSE 1 antibody
      • HSE1 antibody
      see all

    Anti-Heparanase 1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56781 Heparanase 1 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-Heparanase 1 antibody (ab56781)参考文献

    ab56781 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab56781.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"