Anti-Hemoglobin A1c抗体[M0501129] (ab33847)

概述

  • 产品名称Anti-Hemoglobin A1c抗体[M0501129]
    参阅全部 Hemoglobin A1c 一抗
  • 描述
    小鼠单克隆抗体[M0501129] to Hemoglobin A1c
  • 特异性The antibody recognizes human Hemoglobin A1c (the diabetic glycated hemoglobin marker),and all variants of A1c and S1c (the sickle cell glycated hemoglobin marker). The clone number has been updated from (8.F.127A) to (M0501129) both clone numbers name the same antibody clone.
  • 经测试应用适用于: ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Hemoglobin A1c, N-terminal of the beta chain

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: Tris buffered saline, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号M0501129
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab33847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.

靶标

  • 功能Involved in oxygen transport from the lung to the various peripheral tissues.
    LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.
    Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
  • 组织特异性Red blood cells.
  • 疾病相关Heinz body anemias
    Beta-thalassemia
    Sickle cell anemia
    Beta-thalassemia, dominant, inclusion body type
  • 序列相似性Belongs to the globin family.
  • 翻译后修饰Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus.
    S-nitrosylated; a nitric oxide group is first bound to Fe(2+) and then transferred to Cys-94 to allow capture of O(2).
    Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure. PubMed:16916647 reports the identification of HBB acetylated on Lys-145 in the cytosolic fraction of HeLa cells. This may have resulted from contamination of the sample.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta-globin antibody
    • HBB antibody
    • HBB_HUMAN antibody
    • Hemoglobin beta chain antibody
    • Spinorphin antibody
    see all

Anti-Hemoglobin A1c antibody [M0501129] (ab33847)参考文献

ab33847 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiries. Ab33847: This Ab is specific for Human hemoglobin A1C (the diabetic glycated hemoglobin marker); and also recognizes hemoglobin S1C (the sickle cell glycated hemoglobin marker). It does not recognize hemoglobin A. ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"