概述

  • 产品名称Anti-HDAC3抗体
    参阅全部 HDAC3 一抗
  • 描述
    兔多克隆抗体to HDAC3
  • 特异性Detects endogenous levels of total HDAC3 protein.
  • 经测试应用适用于: ELISA, ICC/IF, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from C-terminal of human HDAC3

  • 阳性对照
    • COS7 cells, extracts from HepG2 cells, human breast carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab61216 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/5000.
ICC/IF 1/500 - 1/1000.
IHC-P 1/50 - 1/100.
WB 1/500 - 1/1000. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

靶标

  • 功能Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the histone deacetylase family. HD type 1 subfamily.
  • 翻译后修饰Sumoylated in vitro.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HD3 antibody
    • HDAC 3 antibody
    • HDAC3 antibody
    • HDAC3_HUMAN antibody
    • Histone deacetylase 3 antibody
    • RPD3 2 antibody
    • RPD3 antibody
    • RPD3-2 antibody
    • SMAP45 antibody
    see all

Anti-HDAC3 antibody 图像

  • All lanes : Anti-HDAC3 antibody (ab61216) at 1/500 dilution

    Lane 1 : extracts from HepG2 cells
    Lane 2 : extracts from HepG2 cells with immunizing peptide


    Predicted band size : 49 kDa
    Observed band size : 49 kDa
  • Ab61216 at 1/50-1/100 dilution staining human breast carcinoma tissue without (left) and with (right) immunizing peptide; paraffin embedded.
  • Ab61216 at 1/500-1/1000 dilution staining COS7 cells without (left) and with (right) immunizing peptide.

Anti-HDAC3 antibody (ab61216)参考文献

This product has been referenced in:
  • Pancione M  et al. Right-sided rhabdoid colorectal tumors might be related to the serrated pathway. Diagn Pathol 8:31 (2013). IHC-P ; Human . Read more (PubMed: 23425390) »

See 1 Publication for this product

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