The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/250 - 1/1000. Detects a band of approximately 65-70 kDa.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Ubiquitous. High expression in liver, spleen, pancreas and kidney.
Belongs to the histone deacetylase family. HD type 2 subfamily.