The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明WB: Use at a concentration of 1 - 4 µg/ml. Detects a band of approximately 74 kDa (predicted molecular weight: 71 kDa). A 55 kDa band can also be detected in mouse and rat tissue lysate.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
组织特异性Ubiquitous. High expression in liver, spleen, pancreas and kidney.
序列相似性Belongs to the histone deacetylase family. HD type 2 subfamily.
细胞定位Cytoplasm. Nucleus. Excluded from the nucleoli.