Anti-HCN4抗体(ab66501)
Key features and details
- Rabbit polyclonal to HCN4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-HCN4抗体
参阅全部 HCN4 一抗 -
描述
兔多克隆抗体to HCN4 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human HCN4 (N terminal).
Database link: Q9Y3Q4 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Must be reconstituted with 200ul distilled water. -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab66501于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use at an assay dependent concentration.
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说明 |
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IHC-P
Use at an assay dependent concentration. |
靶标
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相关性
HCN4 is a member of the family of hyperpolarization activated and cyclic nucleotide gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node. -
细胞定位
Membrane; multi pass membrane protein. -
数据库链接
- Entrez Gene: 10021 Human
- Entrez Gene: 330953 Mouse
- Entrez Gene: 59266 Rat
- Omim: 605206 Human
- SwissProt: Q9Y3Q4 Human
- SwissProt: O70507 Mouse
- SwissProt: Q9JKA7 Rat
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别名
- HCN 4 antibody
- Hyperpolarization activated cyclic nucleotide gated potassium channel 4 antibody
- Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 4 antibody
图片
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IHC image of ab66501 staining in human hippocampus formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab66501, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
数据表及文件
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Datasheet download
文献 (4)
ab66501 被引用在 4 文献中.
- Ren L et al. Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. JCI Insight 7:N/A (2022). PubMed: 36509290
- Smit T et al. A Human 3D Cardiomyocyte Risk Model to Study the Cardiotoxic Influence of X-rays and Other Noxae in Adults. Cells 10:N/A (2021). PubMed: 34685588
- Zhong HB et al. Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation. Biomed Res Int 2018:7487324 (2018). PubMed: 30581867
- Pai VP et al. HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner. Biol Open 6:1445-1457 (2017). PubMed: 28818840