Anti-hCG receptor/LHR抗体(ab125214)
Key features and details
- Rabbit polyclonal to hCG receptor/LHR
- Suitable for: WB, IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-hCG receptor/LHR抗体
参阅全部 hCG receptor/LHR 一抗 -
描述
兔多克隆抗体to hCG receptor/LHR -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Rat, Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Preservatives: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab125214于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 79 kDa.
The detection limit for ab125214 is approximately 0.1ng/lane under non-reducing and reducing conditions. |
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IHC-P |
Use a concentration of 0.5 - 1 µg/ml.
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说明 |
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WB
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 79 kDa. The detection limit for ab125214 is approximately 0.1ng/lane under non-reducing and reducing conditions. |
IHC-P
Use a concentration of 0.5 - 1 µg/ml. |
靶标
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功能
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. -
组织特异性
Gonadal and thyroid cells. -
疾病相关
Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.
Defects in LHCGR are the cause of luteinizing hormone resistance (LHR) [MIM:238320]; also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3973 Human
- Entrez Gene: 25477 Rat
- Omim: 152790 Human
- SwissProt: P22888 Human
- SwissProt: P16235 Rat
- Unigene: 468490 Human
- Unigene: 11216 Rat
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别名
- Gonadotropin receptor antibody
- Gpcr19-rs1 antibody
- GTHR-II antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab125214 被引用在 2 文献中.
- Zhang H et al. Seasonal expressions of follicle-stimulating hormone receptor and luteinizing hormone receptor in the scented gland of the male muskrat (Ondatra zibethicus). Am J Physiol Regul Integr Comp Physiol 312:R569-R574 (2017). PubMed: 28228419
- So KH et al. Human chorionic gonadotropin stimulates spheroid attachment on fallopian tube epithelial cells through the mitogen-activated protein kinase pathway and down-regulation of olfactomedin-1. Fertil Steril 104:474-82 (2015). PubMed: 25999259