抗乙型肝炎病毒Core Antigen抗体(ab115992)
Key features and details
- Rabbit polyclonal to Hepatitis B Virus Core Antigen
- Suitable for: IHC-P, IHC-Fr
- Reacts with: Hepatitis B virus
- Isotype: IgG
概述
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产品名称
抗乙型肝炎病毒Core Antigen抗体
参阅全部 Hepatitis B Virus Core Antigen 一抗 -
描述
兔多克隆抗体to乙型肝炎病毒Core Antigen -
宿主
Rabbit -
特异性
Serotype specificity information is not available for this antibody
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经测试应用
适用于: IHC-P, IHC-Frmore details -
种属反应性
与反应: Hepatitis B virus -
免疫原
Full length native protein (purified) corresponding to Hepatitis B Virus Core Antigen.
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阳性对照
- Human liver tissue infected with Hepatitis B virus.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 1.17% Sodium chloride, 0.16% Sodium phosphate -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab115992于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/200 - 1/400.
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IHC-Fr |
1/200 - 1/400.
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说明 |
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IHC-P
1/200 - 1/400. |
IHC-Fr
1/200 - 1/400. |
靶标
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相关性
Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection. -
细胞定位
Capsid protein: Virion. Host cytoplasm, hepatocyte nucleus. -
数据库链接
- Entrez Gene: 2828293 Hepatitis B virus
- Entrez Gene: 944568 Hepatitis B virus
- SwissProt: P03146 Hepatitis B virus
- SwissProt: P03147 Hepatitis B virus
- SwissProt: P03148 Hepatitis B virus
- SwissProt: P0C573 Hepatitis B virus
- SwissProt: P69706 Hepatitis B virus
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别名
- C antibody
- Capsid protein antibody
- Core and e antigen antibody
see all
数据表及文件
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Datasheet download
文献 (10)
ab115992 被引用在 10 文献中.
- Vermes T et al. An automated microfluidic platform for the screening and characterization of novel hepatitis B virus capsid assembly modulators. Anal Methods 14:135-146 (2022). PubMed: 34918017
- Li B et al. Inhibition of Protease Activated Receptor 2 Attenuates HBx-Induced Inflammation and Mitochondria Oxidative Stress. Infect Drug Resist 15:961-973 (2022). PubMed: 35299854
- Clark MP et al. Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models. Cell Death Dis 12:641 (2021). PubMed: 34162831
- Balagopal A et al. Single hepatocytes show persistence and transcriptional inactivity of hepatitis B. JCI Insight 5:N/A (2020). PubMed: 33004689
- Kusama K et al. Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin. Intern Med 59:3075-3078 (2020). PubMed: 32759579
- Ye L et al. Short hairpin RNA attenuates liver fibrosis by regulating the PPAR-? and NF-?B pathways in HBV-induced liver fibrosis in mice. Int J Oncol 57:1116-1128 (2020). PubMed: 33491741
- Liu J et al. Pathological Pattern of Intrahepatic HBV in HCC is Phenocopied by PDX-Derived Mice: a Novel Model for Antiviral Treatment. Transl Oncol 12:1138-1146 (2019). PubMed: 31202090
- Corcuera A et al. Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro. Antiviral Res 158:135-142 (2018). PubMed: 30031759
- Chen K et al. Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity. Cell 170:492-506.e14 (2017). PubMed: 28753426
- Wang Y et al. Enhanced immunity and antiviral effects of an HBV DNA vaccine delivered by a DC-targeting protein. J Viral Hepat 23:798-804 (2016). PubMed: 27126208