概述

  • 产品名称Harmine
  • 描述
    Potent and selective inhibitor of DYRK1A
  • 生物学描述Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08 (DYRK1A), 0.9 (DYRK2), 0.8 (DYRK3), 4.3 (PIM3) and 1.5 μM (CK1)). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.
  • 纯度> 98%

性能

  • 化学名称7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
  • 分子量212.25
  • 化学结构Chemical Structure
  • 分子式C13H12N2O
  • CAS编号442-51-3
  • PubChem识别号5280953
  • 存放说明Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 100 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCOc1ccc3c(c1)nc2c3ccnc2C
  • 来源

    Synthetic

  • 研究领域

    Harmine (ab120225)参考文献

    This product has been referenced in:
    • Waki H  et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab 5:357-70 (2007). Read more (PubMed: 17488638) »
    • Bain J  et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007). Read more (PubMed: 17850214) »
    • Song Y  et al. Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. Biochem Biophys Res Commun 317:128-32 (2004). Read more (PubMed: 15047157) »

    See 0 Publications for this product

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