Harmine,DYRK1A抑制剂(ab120225)
Key features and details
- Potent and selective inhibitor of DYRK1A
- CAS Number: 442-51-3
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Harmine,DYRK1A抑制剂 -
描述
Potent and selective抑制剂of DYRK1A -
生物学描述
Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08 (DYRK1A), 0.9 (DYRK2), 0.8 (DYRK3), 4.3 (PIM3) and 1.5 μM (CK1)). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.
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CAS编号
442-51-3 -
化学结构
性能
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化学名称
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole -
分子量
212.25 -
分子式
C13H12N2O -
PubChem识别号
5280953 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1ccc3c(c1)nc2c3ccnc2C -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab120225 被引用在 2 文献中.
- Kim MJ et al. PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Mol Cell 81:1698-1714.e6 (2021). PubMed: 33626321
- Yamamoto T et al. Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks. FEBS Lett 591:842-853 (2017). PubMed: 28194753