Anti-Haptoglobin抗体(ab75455)

概述

  • 产品名称Anti-Haptoglobin抗体
    参阅全部 Haptoglobin 一抗
  • 描述
    鸡多克隆抗体to Haptoglobin
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human Haptoglobin serum protein.

  • 阳性对照
    • Human serum

性能

应用

Our Abpromise guarantee covers the use of ab75455 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200. Predicted molecular weight: 45 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
    Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
  • 组织特异性Expressed by the liver and secreted in plasma.
  • 疾病相关Anhaptoglobinemia
  • 序列相似性Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
    Contains 2 Sushi (CCP/SCR) domains.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Binding peptide antibody
    • BP antibody
    • Haptoglobin alpha chain antibody
    • Haptoglobin alpha(1S) beta antibody
    • Haptoglobin alpha(2FS) beta antibody
    • Haptoglobin beta chain antibody
    • Haptoglobin, alpha polypeptide antibody
    • Haptoglobin, beta polypeptide antibody
    • HP antibody
    • HP2 ALPHA2 antibody
    • HP2ALPHA2 antibody
    • HPA1S antibody
    • HPT antibody
    • HPT_HUMAN antibody
    • MGC111141 antibody
    • Zonulin antibody
    see all

Anti-Haptoglobin antibody 图像

  • Anti-Haptoglobin antibody (ab75455) at 1/10000 dilution + Human serum at 2 µl

    Secondary
    Goat-anti-IgY/Fc-HRP at 1/10000 dilution

    Predicted band size : 45 kDa
    Observed band size : 45 kDa
  • Blue line: ab75455 at 10 µg/ml vs. mouse anti Hp
    Yellow line: ab75455 at 1 µg/ml vs. mouse anti Hp

Anti-Haptoglobin antibody (ab75455)参考文献

ab75455 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab75455.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"