Anti-Hantavirus nucleocapsid protein抗体(ab34757)

概述

  • 产品名称Anti-Hantavirus nucleocapsid protein抗体
    参阅全部 Hantavirus nucleocapsid protein 一抗
  • 描述
    小鼠单克隆抗体to Hantavirus nucleocapsid protein
  • 特异性Does not cross-react with nucleocapsid proteins of measles and mumps viruses.
  • 经测试应用适用于: Indirect ELISA, WB, ICC/IFmore details
  • 种属反应性
    Reacts with nucleocapsid proteins of Puumala hantaviruses: Vranica, Sotkamo and Kazan and reacts with hantavirus-infected cells. It reacts with nucleocapsid proteins of Andes, Sin Nombre and Seoul hantaviruses. It does not cross-react with hamster polyomavirus major capsid protein VP1 Not yet tested in other species.
  • 免疫原

    Recombinant fragment - recombinant chimeric protein harbouring N-terminal segment (1-120 aa) of Puumala hantavirus (strain Vranica-Hällnäs) nucleocapsid protein, expressed in yeast S.cerevisiae.

  • 表位The epitope recognized by this antibody is localized at N-terminus, between amino acids 1 and 45 of the hantavirus nucleocapsid protein.

性能

应用

Our Abpromise guarantee covers the use of ab34757 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Indirect ELISA 1/1000 - 1/10000.
WB 1/1000 - 1/5000.
ICC/IF Use at an assay dependent dilution. PubMed: 18687679

靶标

  • 相关性The members of the Hantavirus genus of the family Bunyaviridae are spherical, enveloped viruses containing tripartite negative-sense RNA as their genome. The three genomic RNA segments, designated L, M, and S, encode an RNA-dependent RNA polymerase, envelope glycoproteins (G1 and G2), and nucleocapsid (N) protein, respectively. Hantavirus infections can cause two serious and often fatal human diseases, hemorrhagic fever with renal syndrome and hantaviral pulmonary syndrome, characterized by lung damage and cardiac dysfunction. Humans are infected with hantaviruses from rodent reservoirs that are persistently infected without signs of disease.

Anti-Hantavirus nucleocapsid protein antibody 图像

  • ab34757 at 1µg/ml used in Western blot of recombinant nucleocapsid proteins.

    Lane 1 Sotkamo NP

    Lanes 2 & 3 Vranica NP

    Lane 4 Kazan NP

Anti-Hantavirus nucleocapsid protein antibody (ab34757)参考文献

This product has been referenced in:
  • Wang Y  et al. NMR structure of the N-terminal coiled coil domain of the Andes hantavirus nucleocapsid protein. J Biol Chem 283:28297-304 (2008). ICC/IF . Read more (PubMed: 18687679) »

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