概述

  • 产品名称Anti-HAND2抗体
    参阅全部 HAND2 一抗
  • 描述
    小鼠单克隆抗体to HAND2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: LSKIKTLRLA TSYIAYLMDL LAKDDQNGEA EAFKAEIKKT DVKEEKRKKE LNEILKSTVS SNDKKTKGRT GWPQHVWALE LK, corresponding to amino acids 135-217 of Human HAND2

性能

应用

Our Abpromise guarantee covers the use of ab56590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

靶标

  • 功能Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
  • 组织特异性Heart.
  • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • 发展阶段Expressed in the fetal heart.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI225906 antibody
    • AI661148 antibody
    • autonomic nervous system and neural crest derivatives-expressed protein 2 antibody
    • Basic helix loop helix transcription factor HAND2 antibody
    • bHLHa26 antibody
    • Class A basic helix-loop-helix protein 26 antibody
    • Deciduum antibody
    • Deciduum heart autonomic nervous system and neural crest derivatives expressed protein 2 antibody
    • DHAND 2 antibody
    • dHAND antibody
    • DHAND2 antibody
    • Ehand 2 antibody
    • Ehand2 antibody
    • FLJ16260 antibody
    • HAND 2 antibody
    • Hand2 antibody
    • HAND2_HUMAN antibody
    • Heart and neural crest derivatives expressed 2 antibody
    • Heart and neural crest derivatives expressed protein 2 antibody
    • heart and neural crest derivatives expressed transcript 2 antibody
    • heart antibody
    • Heart- and neural crest derivatives-expressed protein 2 antibody
    • Hed antibody
    • Highly similar to dHAND M musculus antibody
    • MGC125303 antibody
    • MGC125304 antibody
    • Th 2 antibody
    • Th2 antibody
    • Thing 2 antibody
    • Thing2 antibody
    see all

Anti-HAND2 antibody 图像

  • Western blot against tagged recombinant protein immunogen using ab56590 HAND2 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

Anti-HAND2 antibody (ab56590)参考文献

This product has been referenced in:
  • Raychaudhuri S MicroRNAs Overexpressed in Growth-Restricted Rat Skeletal Muscles Regulate the Glucose Transport in Cell Culture Targeting Central TGF-ß Factor SMAD4. PLoS One 7:e34596 (2012). Read more (PubMed: 22506032) »

See 1 Publication for this product

Product Wall

Thank you for contacting us.

We have 3 antibodies available in Abcam catalogue; the numbers are ab10131, ab56590 and ab60037. Please choose any one of these for testing.

The terms and conditions for a testing discount can be found at ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"