This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

概述

性能

应用

  • 应用说明This antibody gave a positive result in ELISA against the immunizing peptide (ab37538).
    Not yet tested in other applications.
  • 靶标

    • 功能May act as a transcription factor that could act on to regulate one of the phases of hair growth.
    • 组织特异性Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin.
    • 疾病相关Defects in HR are the cause of alopecia universalis congenita (ALUNC) [MIM:203655]. ALUNC is a rare autosomal recessive form of hair loss characterized by hair follicles without hair.
      Defects in HR are the cause of atrichia with papular lesions (APL) [MIM:209500]; also known as congenital atrichia. APL is an autosomal recessive disease characterized by papillary lesions over most of the body and almost complete absence of hair.
      Defects in HR are the cause of hypotrichosis Marie Unna type 1 (MUHH1) [MIM:146550]. An autosomal dominant condition characterized by reduced amount of hair, alopecia, little or no eyebrows, eyelashes or body hair, and coarse, wiry, twisted hair in early childhood.
    • 序列相似性Contains 1 JmjC domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ALUNC antibody
      • AU antibody
      • HAIR_HUMAN antibody
      • Hairless protein antibody
      • Host range antibody
      • HR antibody
      • HSA277165 antibody
      • Protein hairless antibody
      see all

    Anti-Hairless antibody (ab36682)参考文献

    This product has been referenced in:
    • Malloy PJ  et al. Modulation of vitamin d receptor activity by the corepressor hairless: differential effects of hairless isoforms. Endocrinology 150:4950-7 (2009). WB ; Human, African Green Monkey . Read more (PubMed: 19819974) »

    See 1 Publication for this product

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