Anti-H2A.Z (acetyl K3 + K8 + K10 + K14)抗体(ab43983)

概述

  • 产品名称Anti-H2A.Z (acetyl K3 + K8 + K10 + K14)抗体
    参阅全部 H2A.Z 一抗
  • 描述
    羊多克隆抗体to H2A.Z (acetyl K3 + K8 + K10 + K14)
  • 特异性ab43983 was raised against an acetylated N-terminal H2A.Z peptide at residues K3, K8, K10 and K14. However, it is currently unclear if the antibody recognises all of these modifications or indeed unmodified H2A.Z. Customer feedback on this matter is appreciated.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Saccharomyces cerevisiae
    不与反应: Chicken, Cow
  • 免疫原

    Synthetic peptide corresponding to Saccharomyces cerevisiae H2A.Z aa 1-18 (N terminal) (acetyl K3 + K8 + K10 + K14).
    Sequence:

    SGK(Ac)AHGGK(Ac)GK(Ac)SGAK(Ac)DSGS-C


    Database link: P0C0S5

性能

应用

Our Abpromise guarantee covers the use of ab43983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 14 kDa (predicted molecular weight: 14 kDa).

靶标

  • 功能Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
  • 序列相似性Belongs to the histone H2A family.
  • 翻译后修饰Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
    Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.
    Not phosphorylated.
  • 细胞定位Nucleus. Chromosome.
  • Information by UniProt
  • 别名
    • H2A/z antibody
    • H2afz antibody
    • H2AZ antibody
    • H2AZ_HUMAN antibody
    • Histone H2A.Z antibody
    see all

Anti-H2A.Z (acetyl K3 + K8 + K10 + K14) antibody 图像

  • Anti-H2A.Z (acetyl K3 + K8 + K10 + K14) antibody (ab43983) at 2 µg/ml + S. cerevisiae lysate at 2 µg/ml

    Predicted band size : 14 kDa

Anti-H2A.Z (acetyl K3 + K8 + K10 + K14) antibody (ab43983)参考文献

ab43983 has not yet been referenced specifically in any publications.

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