Anti-H1N1 Influenza A virus Nucleocapsid protein抗体(ab104870)

概述

  • 产品名称Anti-H1N1 Influenza A virus Nucleocapsid protein抗体
    参阅全部 H1N1 Influenza A virus Nucleocapsid protein 一抗
  • 描述
    兔多克隆抗体to H1N1 Influenza A virus Nucleocapsid protein
  • 经测试应用适用于: WB, ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Influenza A
  • 免疫原

    Synthetic peptide derived from internal part of H1N1 Influenza A virus Nucleocapsid protein.

性能

应用

Our Abpromise guarantee covers the use of ab104870 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 56 kDa.

Dilute 1:200 - 1:2000

ELISA Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.

靶标

  • 相关性Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
  • 细胞定位Virion. Host nucleus
  • 数据库链接
    • 别名
      • NP antibody
      • Nucleocapsid protein antibody
      • Nucleoprotein antibody
      • Protein N antibody

    Anti-H1N1 Influenza A virus Nucleocapsid protein antibody (ab104870)参考文献

    ab104870 has not yet been referenced specifically in any publications.

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