概述

  • 产品名称
    GW542573X
  • 描述
    Novel, selective KCa2 channel activator
  • 生物学描述
    Novel activator of KCa2 ('SK') channels. Selective SK1 channel activator (EC50 = 8.2 μM). First true activator of KCa2.x and KCa3.1 channels; displays 100-fold greater selectivity for KCa2.x over KCa3.1.
  • 纯度
    > 99%
  • 常规说明

    Supplied in ethanol (25 mg/ml). Please note this compound is unstable as the solid form and unstable in DMSO

性能

文献

This product has been referenced in:
  • Balut CM  et al. Immunofluorescence-based assay to identify modulators of the number of plasma membrane KCa3.1 channels. Future Med Chem 2:707-13 (2010). Read more (PubMed: 20596245) »
  • Hougaard C  et al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol 76:569-78 (2009). Read more (PubMed: 19515965) »

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