概述

  • 产品名称Anti-GSTM1 + GSTM2抗体
  • 描述
    山羊多克隆抗体to GSTM1 + GSTM2
  • 特异性This antibody is expected to recognise both reported variants of human GSTM1 protein (NP_000552; NP_666533) and GSTM2 protein (NP_000848).
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    CVFSKMAVWGNK

    from the C Terminus of the protein (Human).

  • 阳性对照
    • Human liver and lung lysates for Western blot.

性能

应用

Our Abpromise guarantee covers the use of ab27489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 26 kDa (predicted molecular weight: 26 kDa).

靶标

  • 相关性Glutathione S transferases are encoded by two distinct supergene families and a total of eight distinct classes of the soluble cytoplasmic mammalian glutathione S transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The mu class of these enzymes, to which GSTM1 and 2 belong, functions in the detoxification of electrophilic compounds by conjugation with glutathione. The genes encoding the mu class of enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs and null mutations of this gene have been linked with an increase in a number of cancers.
  • 细胞定位Cytoplasmic
  • 数据库链接
  • 别名
    • Glutathione S alkyltransferase M1 antibody
    • Glutathione S alkyltransferase M2 antibody
    • Glutathione S transferase M1 antibody
    • Glutathione S transferase Mu 1 antibody
    • Glutathione S transferase Mu 2 antibody
    • GST class mu 1 antibody
    • GSTM antibody
    • GTH4 antibody
    • GTM1 antibody
    • S(hydroxyalkyl) glutathione lyase antibody
    see all

Anti-GSTM1 + GSTM2 antibody 图像

  • Anti-GSTM1 + GSTM2 antibody (ab27489) at 0.3 µg/ml + human lung lysate (35µg protein in RIPA buffer).

    Predicted band size : 26 kDa
    Observed band size : 26 kDa

Anti-GSTM1 + GSTM2 antibody (ab27489)参考文献

This product has been referenced in:
  • Shan Y  et al. Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model. Antioxid Redox Signal 19:1481-93 (2013). Read more (PubMed: 23350650) »
  • Yang Y  et al. Glutathione S-Transferase-{mu}1 Regulates Vascular Smooth Muscle Cell Proliferation, Migration, and Oxidative Stress. Hypertension : (2009). Read more (PubMed: 19822795) »

See all 3 Publications for this product

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