概述

  • 产品名称GS 39783
  • 描述
    Novel, GABAB positive allosteric modulator
  • 生物学描述Novel, GABAB positive allosteric modulator (EC50 = 3 μM for [35S]GTPγS binding). Shows anxiolytic and antiaddictive effects in vivo. Blood-brain barrier permeable. Orally active.
  • 纯度> 99%

性能

  • 化学名称N4,N6-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
  • 分子量337.44
  • 化学结构Chemical Structure
  • 分子式C15H23N5O2S
  • CAS编号39069-52-8
  • PubChem识别号6604928
  • 存放说明Store at -20°C. Store at -20°C long term. Store In the Dark. Store under Desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • 溶解度概述Soluble in DMSO to 25 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCSC1=NC(=C(C(=N1)NC2CCCC2)[N+](=O)[O-])NC3CCCC3
  • 来源

    Synthetic

  • 研究领域

    GS 39783 (ab120320)参考文献

    This product has been referenced in:
    • Mombereau C  et al. GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulation. J Pharmacol Exp Ther 321:172-7 (2007). Read more (PubMed: 17215447) »
    • Cryan JF  et al. Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines. J Pharmacol Exp Ther 310:952-63 (2004). Read more (PubMed: 15113848) »
    • Urwyler S  et al. N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function. J Pharmacol Exp Ther 307:322-30 (2003). Read more (PubMed: 12954816) »

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