概述

  • 产品名称Anti-GRXCR1抗体
    参阅全部 GRXCR1 一抗
  • 描述
    兔多克隆抗体to GRXCR1
  • 经测试应用适用于: IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: GVKYKVSAGQ ALFNNLTKVL QQPSTDLEFD RVVIYTTCLR VVRTTFERCE LVRKIFQNHR VKFEEKNIAL NGEYGK, corresponding to amino acids 108-183 of Human GRXCR1.

  • 阳性对照
    • Human nasopharynx tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab122670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

靶标

  • 功能May play a role in actin filament architecture in developing stereocilia of sensory cells.
  • 组织特异性Expressed at low levels in adult lung, brain and duodenum with moderate levels in testis. Highly expressed in fetal cochlea.
  • 疾病相关Defects in GRXCR1 are the cause of deafness autosomal recessive type 25 (DFNB25) [MIM:613285]. DFNB25 is characterized by moderate to severe or profound hearing loss which is progressive in some individuals but not in others. Speech development is impaired in some but not all affected individuals and vestibular dysfunction is observed in some affected individuals.
  • 序列相似性Belongs to the GRXCR1 family.
    Contains 1 glutaredoxin domain.
  • 细胞定位Cell projection > stereocilium. Cell projection > microvillus. Cell projection > kinocilium. In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DFNB25 antibody
    • Glutaredoxin domain-containing cysteine-rich protein 1 antibody
    • Glutaredoxin, cysteine rich 1 antibody
    • GRCR1_HUMAN antibody
    • Grxcr1 antibody
    see all

Anti-GRXCR1 antibody 图像

  • Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus but not nucleoli and cell junctions. Recommended concentration of ab122670 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122670, at 1/50 dilution, staining GRXCR1 in paraffin-embedded Human nasopharynx tissue by Immunohistochemistry.

Anti-GRXCR1 antibody (ab122670)参考文献

ab122670 has not yet been referenced specifically in any publications.

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