Anti-Growth hormone receptor抗体[MM0320-6J33] (ab89304)


  • 产品名称Anti-Growth hormone receptor抗体[MM0320-6J33]
    参阅全部 Growth hormone receptor 一抗
  • 描述
    小鼠单克隆抗体[MM0320-6J33] to Growth hormone receptor
  • 经测试应用适用于: WB, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human protein



Our Abpromise guarantee covers the use of ab89304 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 72 kDa.
Neutralising Use at an assay dependent dilution.


  • 功能Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway.
    The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
    Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
  • 组织特异性Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver.
  • 疾病相关Defects in GHR are a cause of Laron syndrome (LARS) [MIM:262500]. A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone.
    Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA) [MIM:604271]. Short stature is defined by a subnormal rate of growth.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 1 subfamily.
    Contains 1 fibronectin type-III domain.
  • 结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
    The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).
    The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.
  • 翻译后修饰The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17.
    On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.
    On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization.
  • 细胞定位Secreted; Cell membrane. On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway and Cell membrane. Remains fixed to the cell membrane and is not internalized.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GH receptor antibody
    • GH-binding protein antibody
    • GHBP antibody
    • GHBP, included antibody
    • GHR antibody
    • GHR_HUMAN antibody
    • Growth hormone binding protein antibody
    • Growth hormone receptor antibody
    • Growth hormone receptor precursor antibody
    • Growth hormone-binding protein antibody
    • Growth hormone-binding protein, included antibody
    • Increased responsiveness to growth hormone, included antibody
    • Serum binding protein antibody
    • Serum-binding protein antibody
    • Somatotropin receptor antibody
    see all

Anti-Growth hormone receptor antibody [MM0320-6J33] (ab89304)参考文献

ab89304 has not yet been referenced specifically in any publications.

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