Anti-Growth Hormone抗体[KT34] (HRP) (ab106749)

概述

  • 产品名称Anti-Growth Hormone抗体[KT34] (HRP)
    参阅全部 Growth Hormone 一抗
  • 描述
    大鼠单克隆抗体[KT34] to Growth Hormone (HRP)
  • 偶联物HRP
  • 经测试应用适用于: WB, Sandwich ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Human Growth Hormone

性能

应用

Our Abpromise guarantee covers the use of ab106749 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 25 kDa.
Sandwich ELISA 1/1000. Can be paired for Sandwich ELISA with Rat monoclonal [KT19] to Growth Hormone (ab106720). Can be used as detection antibody when paired with ab106720.

靶标

  • 功能Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
  • 疾病相关Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH.
    Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.
    Defects in GH1 are the cause of Kowarski syndrome (KWKS) [MIM:262650]; also known as pituitary dwarfism VI.
    Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
  • 序列相似性Belongs to the somatotropin/prolactin family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • gH antibody
    • GH-N antibody
    • GH1 antibody
    • GHN antibody
    • Growth hormone 1 antibody
    • Growth hormone antibody
    • Growth hormone, normal antibody
    • Growth hormone, pituitary antibody
    • HG1 antibody
    • hGH-N antibody
    • IGHD1B antibody
    • Pituitary growth hormone antibody
    • RNGHGP antibody
    • SOMA_HUMAN antibody
    • Somatotropin antibody
    see all

Anti-Growth Hormone antibody [KT34] (HRP) 图像

  • Sandwich ELISA using a plate coated with a Rat IgG1 monoclonal and HRP conjugated ab106749 at 1/1000 dilution.

Anti-Growth Hormone antibody [KT34] (HRP) (ab106749)参考文献

ab106749 has not yet been referenced specifically in any publications.

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