Anti-GRK6抗体- Carboxyterminal end (ab38291)

概述

  • 产品名称Anti-GRK6抗体- Carboxyterminal end
    参阅全部 GRK6 一抗
  • 描述
    兔多克隆抗体to GRK6 - Carboxyterminal end
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected within aa 500~600 of human GRK6.

  • 阳性对照
    • HeLa cell lysate, Mouse heart tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab38291 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 66 kDa (predicted molecular weight: 66 kDa).
IHC-P 1/50 - 1/100.

靶标

  • 功能Specifically phosphorylates the activated forms of G protein-coupled receptors.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
    Contains 1 RGS domain.
  • 翻译后修饰It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 形式There are 2 isoforms produced by alternative splicing.
  • 别名
    • FLJ32135 antibody
    • G protein coupled receptor kinase 6 antibody
    • G protein coupled receptor kinase GRK6 antibody
    • G protein-coupled receptor kinase 6 antibody
    • G protein-coupled receptor kinase GRK6 antibody
    • Gprk6 antibody
    • Grk6 antibody
    • GRK6_HUMAN antibody
    see all

Anti-GRK6 antibody - Carboxyterminal end 图像

  • All lanes : Anti-GRK6 antibody - Carboxyterminal end (ab38291) at 1/100 dilution

    Lane 1 : HeLa cell lysate.
    Lane 2 : Mouse heart tissue lysate.

    Secondary
    HRP-anti-rabbit.
    Developed using the ECL technique

    Predicted band size : 66 kDa
    Observed band size : 66 kDa
  • ab38291 (1/50) staining human cancer tissue by immunohistochemistry, formalin-fixed, paraffin-embedded tissue. The breast carcinoma tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

Anti-GRK6 antibody - Carboxyterminal end (ab38291)参考文献

This product has been referenced in:
  • Tiedemann RE  et al. Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6. Blood 115:1594-604 (2010). WB ; Human . Read more (PubMed: 19996089) »

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