RabMAb

Anti-GRK1抗体[EPR2039(2)] (ab108502)

概述

  • 产品名称Anti-GRK1抗体[EPR2039(2)]
    参阅全部 GRK1 一抗
  • 描述
    兔单克隆抗体[EPR2039(2)] to GRK1
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human GRK1.

  • 阳性对照
    • Y79 and JAR cell lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab108502 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.
    • 组织特异性Retinal-specific. Expressed in rods and cones cells.
    • 疾病相关Night blindness, congenital stationary, Oguchi type 2
    • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 1 protein kinase domain.
      Contains 1 RGS domain.
    • 翻译后修饰Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.
      Farnesylation is required for full activity.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • EC=2.7.11.14 antibody
      • G protein-coupled receptor kinase 1 antibody
      • GPRK1 antibody
      • Grk1 antibody
      • Rhodopsin kinase antibody
      • RHOK antibody
      • RK antibody
      • RK_HUMAN antibody
      see all

    Anti-GRK1 antibody [EPR2039(2)] 图像

    • All lanes : Anti-GRK1 antibody [EPR2039(2)] (ab108502) at 1/1000 dilution

      Lane 1 : Y79 cell lysate
      Lane 2 : JAR cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 60 kDa
      Observed band size : 60 kDa

    Anti-GRK1 antibody [EPR2039(2)] (ab108502)参考文献

    ab108502 has not yet been referenced specifically in any publications.

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