Anti-GRIM19抗体[EPR4471(2)] (ab109017)


  • 产品名称Anti-GRIM19抗体[EPR4471(2)]
    参阅全部 GRIM19 一抗
  • 描述
    兔单克隆抗体[EPR4471(2)] to GRIM19
  • 经测试应用适用于: WB, IHC-P, ICCmore details
    不适用于: Flow Cyt or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) (internal sequence)

  • 阳性对照
    • HeLa, Ramos, Jurkat, and 293T cell lysates; Human kidney tissue
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


Our Abpromise guarantee covers the use of ab109017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 17 kDa.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC 1/50 - 1/100.
  • 应用说明Is unsuitable for Flow Cyt or IP.
  • 靶标

    • 功能Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
    • 组织特异性Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
    • 疾病相关Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]. Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms.
    • 序列相似性Belongs to the complex I NDUFA13 subunit family.
    • 发展阶段Expressed in numerous fetal tissues.
    • 细胞定位Mitochondrion inner membrane. Nucleus. May be translocated into the nucleus upon IFN/RA treatment.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 2700054G14Rik antibody
      • AU022060 antibody
      • B16.6 antibody
      • CDA016 antibody
      • Cell death regulatory protein antibody
      • Cell death regulatory protein GRIM-19 antibody
      • CGI-39 antibody
      • CGI39 protein antibody
      • CI-B16.6 antibody
      • Complex I-B16.6 antibody
      • FLJ58045 antibody
      • FLJ59191 antibody
      • Gene associated with retinoic and IFN-induced mortality 19 protein antibody
      • Gene associated with retinoic and interferon-induced mortality 19 protein antibody
      • Gene associated with retinoic interferon induced mortality 19 protein antibody
      • GRIM-19 antibody
      • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 antibody
      • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 antibody
      • NADH ubiquinone oxidoreductase B16.6 subunit antibody
      • NADH-ubiquinone oxidoreductase B16.6 subunit antibody
      • NDUAD_HUMAN antibody
      • NDUFA13 antibody
      • RGD1565358 antibody
      see all

    Anti-GRIM19 antibody [EPR4471(2)] 图像

    • All lanes : Anti-GRIM19 antibody [EPR4471(2)] (ab109017) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : Ramos cell lysate
      Lane 3 : Jurkat cell lysate
      Lane 4 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 17 kDa
    • Immunohistochemical analysis of GRIM19 in paraffin-embedded Human kidney tissue using ab109017 at 1/100 dilution.

    Anti-GRIM19 antibody [EPR4471(2)] (ab109017)参考文献

    ab109017 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab109017.
    Please use the links above to contact us or submit feedback about this product.